Streptozocin: High-Dose for SCT (Generic Name)

Other Names: Zanosar®

About This Drug

Streptozocin is used to treat cancer. This drug is given intravenously (IV).

Possible Side Effects

  • Bone marrow depression. This is a decrease in the number of white blood cells, red blood cells, and platelets. Bone marrow depression usually occurs seven to 14 days after the drug is given and may increase your risk of infection, fatigue, and bleeding.
  • Nausea and vomiting. These symptoms may occur within hours after you receive the drug and may last up to 24 hours.
  • Burning sensation at the IV site
  • Sexual problems and reproduction concerns may occur. In men and women both, this drug may temporarily or permanently affect your ability to have children. This cannot be determined before your therapy. In men, this drug may interfere with your ability to make sperm, but it should not change your ability to have sexual relations. In women, menstrual bleeding may become irregular or stop while you are receiving this drug. Do not assume that you cannot become pregnant if you do not have a menstrual period. Women may experience signs of menopause like vaginal dryness or itching.
      • This drug may have harmful effects on the unborn child, so effective methods of birth control should be used during your cancer treatment.
      • Genetic counseling is available to you to discuss the effect of this drug therapy on future pregnancies. In addition, a genetic counselor can review the potential risks of problems in the fetus due to this medication if an exposure during pregnancy has occurred.
  • Changes in kidney function. This drug may affect how your kidneys work. Your kidney function will be checked as needed.
  • Lung tissue changes may occur with high amounts of this drug. These changes may not be permanent and your lung tissue may return to normal. Sometimes these changes may not be seen for many years. You may develop a cough or have difficulty catching your breath.
  • Effects on the pancreas that may result in high blood sugars. You may experience increased urination, thirst, or weakness.

Treating Side Effects

  • Ask your doctor or nurse about medication that is available to help prevent or lessen nausea and vomiting.
  • Use effective methods of birth control during your cancer treatment.
  • Vaginal lubricants can be used to lessen vaginal dryness, itching, and pain during sexual relations.
  • Speak with your doctor or nurse if you plan to have children. Ask for information on sperm or egg banking.

Food and Drug Interactions

Glucose intolerance may occur when you are taking this drug. Avoid concentrated sweets. Speak to your doctor, nurse, or nutritionist if your blood sugar becomes abnormally elevated. This drug may interact with other medications. Tell your doctor and pharmacist all the medications that you are currently taking.

When to Call the Doctor

Call your doctor or nurse immediately if you have any of the following symptoms:

  • Burning at the IV site
  • Temperature of 100.5 F (38 C) or above
  • Chills
  • Unusual bleeding or bruising
  • Uncontrolled nausea that prevents you from eating or drinking
  • Swelling of ankles
  • Difficulty catching your breath
  • Decreased urination

Call your doctor or nurse as soon as possible if you have any of the following symptoms:

  • Nausea unrelieved by prescribed medication
  • Extreme fatigue that interferes with normal activities
  • Increased urination or thirst

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