Leucovorin Calcium (Generic Name)

Leucovorin, Wellcovorin®, Folinic Acid, Citrovorum Factor (Other Names)

About This Drug

Leucovorin is a vitamin. It is used in combination with other cancer fighting drugs such as 5-fluorouracil and methotrexate. Leucovorin helps 5-fluorouracil kill the cancer cells. It also helps to reduce the side effects of methotrexate. Leucovorin is given intravenously (IV) or orally (by mouth).

Possible Side Effects

Leucovorin by itself has very few side effects. Side effects you may have can be caused by the other drugs you are taking, such as 5-fluorouracil or methotrexate.

  • Rash with or without itching, redness, or hives
  • Wheezing

Allergic Reactions

Allergic reactions to this drug are rare. While you are receiving this drug by IV, tell your nurse immediately if you have any of the following symptoms of an allergic reaction:

  • Difficulty catching your breath
  • Feeling like your tongue or throat are swelling.
  • Feeling your heart beat rapidly (palpitations)
  • Dizziness or lightheadedness
  • Flushing/itching/rash/hives

If you are taking the oral form of leucovorin and you have these symptoms, do not take another dose of this drug and seek immediate medical treatment.

Reproduction Concerns

  • Pregnancy warning: It is not known if this drug may have harmful effects on the unborn child. If this reason, be sure to speak with your doctor if you are pregnant or planning to become pregnant while receiving this drug.
  • Genetic counseling is available to you to discuss the potential risks of problems in the fetus due to this medication if an exposure during pregnancy has occurred.
  • Breast feeding warning: It is not known if this drug is safe for breast feeding. Speak with your doctor if you are considering breast feeding while you are on this drug.

Treating Side Effects

Do not put anything on your rash unless your doctor or nurse says you may. Keep the area around the rash clean and dry. Ask your doctor for medication if your rash is bothersome.

Food and Drug Interactions

There are no known interactions of leucovorin with food. This drug may interact with other medication. Tell your doctor and pharmacist about all the medication and dietary supplements (vitamins, minerals, herbs and others) that you are currently taking. The safety and effectiveness of dietary supplements and alternative diets are often unknown. Using these might unexpectedly affect your cancer or interfere with your treatment. Until more is known, you should not use dietary supplements or alternative diets without your cancer doctor's advice.

When to Call the Doctor

Call your doctor or nurse immediately if you have any of the following symptoms:

  • Vomiting (if you take leucovorin orally)
  • Diarrhea (if you take leucovorin orally)
  • Wheezing
  • Rash with or without itching, redness, or hives

Revised February 2013

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