Floxuridine (Generic Name)

Other Names: FUDR®

About This Drug

Floxuridine is used to treat cancer. This drug is given through an artery.

Possible Side Effects

  • Allergic reactions to this drug are rare, but may occur in some patients. Signs of allergic reaction are shortness of breath, rash or itching, dizziness or lightheadedness, or palpitations (feeling your heart beat rapidly).
  • Bone marrow depression. This is a decrease in the number of white blood cells, red blood cells, and platelets. This may increase your risk of infection, fatigue, and bleeding.
  • Stomach pain or cramps
  • Soreness of the mouth, lips, and throat. You may have red areas, white patches, or sores that are painful.
  • Swelling or soreness of the tongue
  • Mild nausea and vomiting
  • Hair loss. Most patients experience scalp and body hair loss. You may notice hair thinning several days after receiving this drug. Usually hair loss is temporary; your hair should grow back when treatment is completed.
  • Redness, pain, warmth, or swelling at the IV site
  • Black, tarry stools
  • Mild to moderately severe diarrhea that may last for several days
  • Fever or chills
  • Changes in kidney function. Your kidney function will be checked as needed.
  • Chest pain
  • Raised, red rash on your arms, legs, back, or chest
  • Pinpoint-size red spots on the skin
  • Scaling or redness of hands or feet
  • Itching of skin
  • Decreased appetite
  • Heartburn
  • Coughing
  • Hoarseness
  • Yellowing of the eyes or skin
  • Difficult or painful urination
  • Blood in the urine
  • Lower back or side pain
  • Drowsiness
  • Seizures
  • Loss of function on one side of the body
  • Depression
  • Trouble keeping your balance
  • Difficulty walking or changes in the way you walk
  • Hiccups
  • Blurred vision
  • Twitching of the eye
  • Changes in liver enzymes. Liver enzymes will be checked as needed.
  • This drug may have harmful effects on the unborn child, so effective methods of birth control should be used during your cancer treatment.

Treating Side Effects

  • Mouth care is very important. Your mouth care should consist of gently brushing with a very soft tooth brush and rinsing your mouth with a mixture of 1/2 teaspoon of salt in 8 ounces of water or 1/2 teaspoon of sodium bicarbonate (baking soda) in 8 ounces of water. This should be done at least after every meal and at bedtime.
  • Avoid mouthwash that contains alcohol. Avoid alcohol and smoking because they can irritate your mouth and throat.
  • Ask your doctor or nurse about medication to help prevent or lessen nausea and vomiting and diarrhea.
  • Talk to your doctor or nurse about obtaining a wig before you experience hair loss.
  • Do not put anything on your rash unless your doctor or nurse says you may. Keep the area around the rash clean and dry.
  • Be careful when cooking, walking, and handling sharp objects and hot liquids.
  • Use effective methods of birth control during your cancer treatment.

Food and Drug Interactions

There are no known interactions of floxuridine and any food. This drug may interact with other medications. Tell your doctor and pharmacist all the medications that you are currently taking.

When to Call the Doctor

Call your doctor or nurse immediately if you have any of the following symptoms:

  • Temperature of 100.5 F (38 C) or above
  • Chills
  • Difficulty catching your breath
  • Rash or itching, dizziness or lightheadedness, or palpitations
  • Unusual bleeding or bruising
  • Uncontrolled nausea that prevents you from eating or drinking
  • Vomiting more than three times in one day
  • Chest pain
  • Difficult or painful urination
  • Blood in the urine
  • Lower back or side pain
  • Coughing
  • Dizziness
  • Stomach pain or cramps
  • Black, tarry stools
  • Seizures
  • Loss of function on one side of the body


Call your doctor or nurse as soon as possible if you have any of the following symptoms:

  • Painful mouth or throat that makes it difficult to eat or drink
  • Diarrhea of five or six stools in one day or diarrhea with weakness or lightheadedness
  • Nausea unrelieved by prescribed medication
  • Yellowing of the skin or eyes
  • Difficulty walking or changes in the way you walk
  • Depression
  • Hiccups
  • Hoarseness
  • Changes in vision, such as blurred or double vision
  • Painful or difficult urination
  • Urinating smaller amounts than usual
  • Persistent loss of appetite or weight loss of five pounds or more in one week
  • Extreme drowsiness
  • Rash that is bothersome
  • Twitching of the eye

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