Autonomic neuropathy is a group of symptoms that occur when there is damage to the nerves that manage every day body functions such as blood pressure, heart rate, sweating, bowel and bladder emptying, and digestion.
Neuropathy - autonomic; Autonomic nerve disease
Causes, incidence, and risk factors
Autonomic neuropathy is a group of symptoms, not a specific disease. There are many causes.
Autonomic neuropathy involves damage to the nerves that carry information from the brain and spinal cord to the heart, bladder, intestines, sweat glands, pupils, and blood vessels.
Autonomic neuropathy may be seen with:
Symptoms vary depending on the nerves affected. They usually develop gradually over years. Symptoms may include:
Stomach and intestines
- Constipation (hard stools)
- Diarrhea (loose stools)
- Feeling full after only a few bites (early satiety
- Nausea after eating
- Problems controlling bowel movements
- Swallowing problems
- Swollen abdomen
- Vomiting of undigested food
Heart and lungs
- Abnormal heart rate or rhythm
- Blood pressure changes with position and causes dizziness when standing
- High blood pressure
- Shortness of breath with activity or exercise
- Sweating too much or not enough
- Heat intolerance
brought on with activity and exercise
- Sexual problems including erection problems in men and vaginal dryness and orgasm difficulties in women
- Small pupil in one eye
- Weight loss without trying
Signs and tests
Signs of autonomic nerve damage are not always seen when yourdoctor or nurse examines you. Your blood pressure or heart rate may change when lying down, sitting, and standing.
Special tests to measure sweating and heart rate may be done. This is called "autonomic testing."
Other tests depend on what type of symptoms you have.
Treatment to reverse nerve damage is most often not possible. As a result, treatment and self-care are focused on managing your symptoms and preventing further problems.
Your doctor or nurse may recommend:
Extra salt in the diet or taking salt tablets to increase fluid volume in blood vessels
Fludrocortisone or similar medications to help your body retain salt and fluid
Medicines to treat irregular heart rhythms
Sleeping with the head raised
Wearing elastic stockings
The following may help your intestines and stomach work better:
Medicines and self-care programs can help you if you have:
How well you do depends on the cause of the problem and if it can be treated.
- Fluid or electrolyte
imbalance such as low blood potassium (if excessive vomiting or diarrhea)
- Injuries from falls (with postural dizziness)
- Kidney failure
(from urine backup)
- Psychological/social effects of impotence
Calling your health care provider
Call for an appointment with your health care provider if you have symptoms of autonomic neuropathy. Early symptoms might include:
Becoming faint or lightheaded when standing
Changes in bowel, bladder, or sexual function
Unexplained nausea and vomiting when eating
Early diagnosis and treatment increases the likelihood of controlling symptoms.
Autonomic neuropathy may hide the warning signs of a heart attack. They are sudden fatigue, sweating, shortness of breath, nausea, and vomiting.
Preventing or controlling disorders associated with autonomic neuropathy may reduce the risk. For example, people with diabetes should closely control blood sugar levels
Shy ME. Peripheral neuropathies. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 446.
Benarroch E, Freeman R, Kaufman H. Autonomic nervous system. In: Goetz CG, eds. Textbook of Clinical Neurology. 3rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 21.
Chelimsky T, Robertson D, Chelimsky G. Disorders of the Autonomic Nervous System. In: Daroff: Bradley's Neurology in Clinical Practice. 6th ed. Philadelphia,Pa; Elsevier; 2012: chap 77.
Luc Jasmin, MD, PhD, Department of Neurosurgery at Cedars-Sinai Medical Center, Los Angeles, and Department of Anatomy at UCSF, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.