Navigate Up

Neurology Center - A-Z Index

#
J
Q
X
Y
Z

Print This Page

Tardive dyskinesia

Tardive dyskinesia is a disorder that involves involuntary movements, especially of the lower face. Tardive means "delayed" and dyskinesia means "abnormal movement."

Causes, incidence, and risk factors

Tardive dyskinesia is a serious side effect that occurs when you take medications called neuroleptics. Most often, it occurs when you take the medication for many months or years, but in some cases it can occur after you take them for as little as 6 weeks.

The drugs that most commonly cause this disorder are older antipsychotic drugs, including:

  • Chlorpromazine
  • Fluphenazine
  • Haloperidol
  • Trifluoperazine

Other drugs, similar to these antipsychotic drugs, that can cause tardive dyskinesia include:

  • Flunarizine (Sibelium)
  • Metoclopramide
  • Prochlorperazine

Newer antipsychotic drugs seem less likely to cause tardive dyskinesia, but they are not entirely without risk.

Symptoms

  • Facial grimacing
  • Finger movement
  • Jaw swinging
  • Repetitive chewing
  • Tongue thrusting

Expectations (prognosis)

If diagnosed early, the condition may be reversed by stopping the drug that caused the symptoms. Even if the antipsychotic drugs are stopped, the involuntary movements may become permanent and in some cases may become significantly worse.

References

Kompoliti K, Horn SS, eds. Drug-induced and iatrogenic neurological disorders. In: Goetz CG, ed. Textbook of Clinical Neurology. 3rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 55.

Lang A. Other movement disorders. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 434.

Updated: 5/21/2012

Luc Jasmin, MD, PhD, Department of Neurosurgery at Cedars-Sinai Medical Center, Los Angeles, and Department of Anatomy at UCSF, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.


©  UPMC | Affiliated with the University of Pittsburgh Schools of the Health Sciences
Supplemental content provided by A.D.A.M. Health Solutions. All rights reserved.

For help in finding a doctor or health service that suits your needs, call the UPMC Referral Service at 412-647-UPMC (8762) or 1-800-533-UPMC (8762). Select option 1.

UPMC is an equal opportunity employer. UPMC policy prohibits discrimination or harassment on the basis of race, color, religion, ancestry, national origin, age, sex, genetics, sexual orientation, marital status, familial status, disability, veteran status, or any other legally protected group status. Further, UPMC will continue to support and promote equal employment opportunity, human dignity, and racial, ethnic, and cultural diversity. This policy applies to admissions, employment, and access to and treatment in UPMC programs and activities. This commitment is made by UPMC in accordance with federal, state, and/or local laws and regulations.

Medical information made available on UPMC.com is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have. Further, UPMC.com is not a tool to be used in the case of an emergency. If an emergency arises, you should seek appropriate emergency medical services.

For UPMC Mercy Patients: As a Catholic hospital, UPMC Mercy abides by the Ethical and Religious Directives for Catholic Health Care Services, as determined by the United States Conference of Catholic Bishops. As such, UPMC Mercy neither endorses nor provides medical practices and/or procedures that contradict the moral teachings of the Roman Catholic Church.

© UPMC
Pittsburgh, PA, USA UPMC.com