Navigate Up

Heart Center - A-Z Index

#
J
Q
X
Z

Print This Page

Hepatitis C

Hepatitis C is a viral disease that leads to swelling (inflammation) of the liver.

Click to download

Other types of viral hepatitis include:

Causes, incidence, and risk factors

Hepatitis C infection is caused by the hepatitis C virus (HCV).

Hepatitis C

You can catch hepatitis C if the blood of someone who has hepatitis C enters your body. Exposure may occur:

People at risk of hepatitis C are those who:

  • Inject street drugs or share a needle with someone who has hepatitis C
  • Have been on long-term kidney dialysis
  • Have regular contact with blood at work (such as a health care worker)
  • Have unprotected sexual contact with a person who has hepatitis C
  • Were born to a mother who had hepatitis C
  • Received a tattoo or acupuncture with needles that were not disinfected properly after being used on another person (risk is very low with practitioners who have a tattoo license or permit or an acupuncture license)
  • Received an organ transplant from a donor who has hepatitis C
  • Share personal items such as toothbrushes and razors with someone who has hepatitis C (less common)
  • Received a blood transfusion (rare in the U.S.)

Symptoms

Most people who are recently infected with hepatitis C do not have symptoms. Some people have yellowing of the skin (jaundice) that goes away. Chronic infection usually causes no symptoms. But tiredness, skin disorders and other problem can occur. Persons who have long-term (chronic) infection often have no symptoms until their liver becomes scarred (cirrhosis ). Most people with this condition are ill and have many health problems.

The following symptoms may occur with hepatitis C infection:

  • Pain in the right upper abdomen
  • Abdominal swelling due to fluid (ascites )
  • Clay-colored or pale stools
  • Dark urine
  • Fatigue
  • Fever
  • Itching
  • Jaundice
  • Loss of appetite
  • Nausea and vomiting

Exams and tests

Blood tests are done to check for hepatitis C:

  • EIA assay to detect hepatitis C antibody
  • Hepatitis C RNA assays to measure virus levels (viral load)

A one-time screening for hepatitis C is now recommended for everyone born from 1945 to 1965 (the "Baby Boom" generation).

Genetic testing is done to check for the type of hepatitis C (genotype). Six genotypes exist (genotypes 1 through 6). Test results can help your doctor choose treatment that is best for you.

The following tests are done to identify and monitor liver damage from hepatitis C:

Treatment

Common medicines used include peginterferon and antiviral drugs. These medicines are aimed at:

  • Helping the body get rid of the virus.
  • Reducing the risk of cirrhosis and liver cancer, which can result from long-term HCV infection.

For these medicines to work best, you need to take them as instructed by your health care provider. Ask what side effects you can expect and what to do if you have them.

liver transplant  may be recommended for persons who develop cirrhosis and liver cancer. Your health care provider can tell you more about liver transplant.

If you have hepatitis C:

  • Do not take over-the-counter medicines that you have not taken before without asking your health care provider. Also ask about vitamins and other supplements.
  • Do not use alcohol or street drugs. Alcohol can speed up the damage to your liver. It can also reduce how well medicines work.
  • Ask your health care provider whether you need the hepatitis A and hepatitis B vaccines.

Support Groups

Joining a support group can help ease the stress of having hepatitis C. Ask your health care provider about liver disease resources  and support groups in your area.

Expectations (prognosis)

Most people with hepatitis C infection have the chronic form. Persons with genotype 2 or 3 are more likely to respond to treatment than those with genotype 1.

The goal of treatment is to reduce the chance of liver damage and liver cancer. A good response to treatment occurs when the virus is no longer detected in the blood after treatment. New and more effective medicines are being developed. As a result, more and more persons with HCV are able to avoid serious liver damage and even liver cancer.

Calling your health care provider

Call your health care provider if:

  • You develop symptoms of hepatitis
  • You believe you have been exposed to the hepatitis C virus

Prevention

Things that can be done to prevent the spread of hepatitis C from one person to another include:

  • Health care workers should follow precautions when handling blood.
  • Do not share needles with anyone.
  • Do not get tattoos or body piercings or receive acupuncture from someone who does not have a permit or license.
  • Do not share personal items such as razors and toothbrushes.
  • Practice safer sex .

If you or your partner is infected with hepatitis C and you have been in a stable and monogamous (no other partners) relationship, the risk of giving the virus to, or getting the virus from, the other person is low.

Hepatitis C virus cannot be spread by casual contact, such as holding hands, kissing, coughing or sneezing, breastfeeding, sharing eating utensils or drinking glasses.

Currently there is no vaccine for hepatitis C.

References

Ghany MG, Strader DB, Thomas DL, Seeff LB. American Association for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology. 2009;49:1335-1374.

Jou JH, Muir AJ. In the clinic. Hepatitis C. Ann Intern Med. 2008;148:ITC6-1-ITC6-16.

Moyer VA; U.S. Preventive Services Task Force. Screening for hepatitis C virus infection in adults: U.S. Preventive services task force recommendation statement. Ann Intern Med. 2013 Sep 3;159(5):349-57.

O'Leary JG, Davis GL. Hepatitis C. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, PA: Elsevier Saunders; 2010:chap 79.

Rosen HR. Clinical practice. Chronic hepatitis C infection. N Engl J Med. 2011;364(25):2429-38.

Updated: 11/16/2012

George F. Longstreth, MD, Department of Gastroenterology, Kaiser Permanente Medical Care Program, San Diego, California. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, David R. Eltz, Stephanie Slon, and Nissi Wang.


©  UPMC | Affiliated with the University of Pittsburgh Schools of the Health Sciences
Supplemental content provided by A.D.A.M. Health Solutions. All rights reserved.

For help in finding a doctor or health service that suits your needs, call the UPMC Referral Service at 412-647-UPMC (8762) or 1-800-533-UPMC (8762). Select option 1.

UPMC is an equal opportunity employer. UPMC policy prohibits discrimination or harassment on the basis of race, color, religion, ancestry, national origin, age, sex, genetics, sexual orientation, marital status, familial status, disability, veteran status, or any other legally protected group status. Further, UPMC will continue to support and promote equal employment opportunity, human dignity, and racial, ethnic, and cultural diversity. This policy applies to admissions, employment, and access to and treatment in UPMC programs and activities. This commitment is made by UPMC in accordance with federal, state, and/or local laws and regulations.

Medical information made available on UPMC.com is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have. Further, UPMC.com is not a tool to be used in the case of an emergency. If an emergency arises, you should seek appropriate emergency medical services.

For UPMC Mercy Patients: As a Catholic hospital, UPMC Mercy abides by the Ethical and Religious Directives for Catholic Health Care Services, as determined by the United States Conference of Catholic Bishops. As such, UPMC Mercy neither endorses nor provides medical practices and/or procedures that contradict the moral teachings of the Roman Catholic Church.

© UPMC
Pittsburgh, PA, USA UPMC.com