Gynecologic Cancer Research and Clinical Trials

Physician-researchers at the Magee-Womens Gynecologic Cancer Program and the University of Pittsburgh Cancer Institute (UPCI) are pioneering efforts to develop novel strategies for diagnosing, treating, and preventing cancers of the cervix, ovaries, uterus, fallopian tubes, vagina, and vulva, helping to establish more personalized treatments, and improve early detection methods for these cancers.

During your testing and treatment, you may be asked to participate in a clinical trial. Part of our mission is the development of new treatments for cancer, and your participation can help us to help others now and in the future.

You can participate in the latest clinical trials for the prevention and treatment of gynecologic cancers through the Magee-Womens Research Institute and the Gynecologic Disease Site at UPCI.

Current research focus for the Gynecologic Cancer Program includes:

  • Sentinel node mapping in the management of cervical and uterine cancers
  • Intraperitoneal biological therapies and the use of combined positron emission tomography/computerized tomography (PET-CT) imaging for the management of ovarian cancer
  • Prevention strategies, including cervical cancer vaccines and the development of new ovarian cancer biomarkers

The Jennie K. Scaife Ovarian Cancer Center of Excellence supports innovative, translational ovarian cancer research projects aimed at improved early detection, diagnosis, treatment, or prevention of ovarian cancer.

The Magee-Womens Gynecologic Cancer Program is a full member of the Gynecologic Oncology Group (GOG) — a national consortium of women's cancer specialists — responsible for the development and implementation of large-scale clinical trials.

Radiation Therapy Research for Gynecologic Cancer

Our researchers are also looking for ways to use radiation therapy for treating cancers of the cervix, uterus, vagina, and vulva.

See recent publications from our expert staff:

Beriwal S, Heron DE, Kim H, King G, Shogan J, Bahri S, Gerszten K, Lee J, Kelley J, Edwards RP. Intensity-Modulated Radiotherapy for the Treatment of Vulvar Carcinoma: a Comparative Dosimetric Study with Early Clinical Outcome. Int J Radiat Oncol Biol Phys. 64(5):1395-1400, 2006, PMID: 16442238.

Beriwal S, Jain SK, Heron DE, Kim H, Gerszten K, Edwards RP, Kelley JL. Clinical Outcome with Adjuvant Treatment of Endometrial Carcinoma Using Intensity Modulated Radiation Therapy. Gynecol Oncol. 102(2):195-199, 2006, PMID: 16647748.

Beriwal S, Gan GN, Heron DE, Selvaraj RN, Kim H, Lalonde R, Kelley JL, Edwards RP. Early Clinical Outcome with Concurrent Chemotherapy and Extended-field, Intensity-modulated Radiotherapy for Cervical Cancer. Int J Radiat Oncol Biol Phys. 68(1):166-171, 2007, PMID: 17321070.

Coon D, Beriwal S, Heron DE, Kelley JL, Edwards RP, Sukumvanich P, Zorn KK, Krivak TC. High-Dose-Rate Rotte “Y” Applicator Brachytherapy for Definitive Treatment of Medically Inoperable Endometrial Cancer: 10-Year Results. Int J Radiat Oncol Biol Phys. 71(3):779-783, 2008, PMID: 18258388.

Beriwal S, Coon D, Heron DE, Kelley JL, Edwards RP, Sukumvanich P, Zorn KK, Krivak TC. Preoperative Intensity-modulated Radiotherapy and Chemotherapy for Locally Advanced Vulvar Carcinoma. Gynecol Oncol. 109(2):291-295, 2008, PMID: 18455637.

Beriwal S, Kim H, Coon D, Mogus R, Heron DE, Li X, Huq MS. Single Magnetic Resonance Imaging vs Magnetic Resonance Imaging/Computer Tomography Planning in Cervical Cancer Brachytherapy. Clin Oncol.  21(6):483-487, 2009, PMID: 19423307.

Beriwal S, Rwigema JC, Higgins E, Kim H, Houser C, Sukumvanich P, Olawaiye A, Richard S, Kelley JL, Edwards RP, Krivak TC.  3D image-based HDR interstitial brachytherapy for vaginal cancer. Brachytherapy. 2011 Jun 10. PMID: 21665553.

Books and book chapters

Paulino AC, The BS (eds.) Godette K, Galli Guevara M, Beriwal S. Gynecologic Cancer pp. 160-173. Chapter in PET-CT in Radiotherapy Treatment Planning. First Edition, 2008.

Viswanathan AN, Kiristis C, Erickson BE, Pötter (eds.) Parikh S, Beriwal S. The Integration of 3D Imaging with Conformal Radiotherapy for Vulvar and Vaginal Cancer, pp 85-95. Gynecologic Radiation Therapy. Springer-Verlag Berlin Heidelberg 2011. 

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